What is Cornforth rearrangement?
The Cornforth rearrangement refers to a chemical reaction where 4-carbonyl substituted oxazoles undergo thermal rearrangement, resulting in the formation of isomeric oxazoles through the use of dicarbonyl nitrile ylides.
References
J. W. Cornforth, The chemistry of penicillin. Clarke H.T., Johnson J.R., and Robinson R. (eds) Princeton University Press, New Jersey, 1949, p 700.
Full Professor of Organic Chemistry at the University of Granada, with a long-standing research career in Computational Chemistry and molecular modeling and design.