Buchwald-Hartwig amination

What is Buchwald-Hartwig amination?

The Buchwald-Hartwig amination reaction is a method for producing arylamine products. It involves reacting aryl halides with secondary amines in the presence of a silylamide base and tri-o-tolyphopshine palladium complexes. The resulting reaction yields the desired arylamine products.

Buchwald–Hartwig amination
Buchwald-Hartwig amination
  • X = Br, I, OTf
  • R = o-alkyl, p-alkyl, CN, C(O)Ph, C(O)NEt2 (see acronyms)
  • R’ = alkyl, aryl