Chichibabin amination

What is Chichibabin amination?

The Chichibabin amination, also known as Chichibabin reaction, is a chemical process that involves the introduction of an amino group to pyridines and other heterocyclic nitrogen compounds using alkali-metal amides. The reaction produces a primary amine, which can be subjected to further chemical modifications to enhance its functionality.

Chichibabin amination - Chichibabin reaction
Chichibabin amination

The origin of this reaction can be traced back to the early 20th century when Alexander Chichibabin, a renowned Russian chemist, reported the reaction in 1914. As a tribute to his significant contribution to the field of chemistry, the reaction has since been named after him and is widely known as the Chichibabin reaction.


A.E. Chichibabin, O.A. Zeide, J. Russ. Phys. Chem. Soc. 46, 1216 (1914)