Cornforth rearrangement

What is Cornforth rearrangement?

The Cornforth rearrangement refers to a chemical reaction where 4-carbonyl substituted oxazoles undergo thermal rearrangement, resulting in the formation of isomeric oxazoles through the use of dicarbonyl nitrile ylides.

Cornforth rearrangement
Cornforth rearrangement

References

J. W. Cornforth, The chemistry of penicillin. Clarke H.T., Johnson J.R., and Robinson R. (eds) Princeton University Press, New Jersey, 1949, p 700.

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