Hunsdiecker reaction

What is Hunsdiecker reaction?

The Hunsdiecker reaction, also known as the Borodine reaction, Hunsdiecker decarboxylation, Hunsdiecker bromodecarboxylation, Hunsdiecker degradation, or Hunsdiecker-Borodine reaction, is a process for generating organic halides through the thermal decarboxylation of silver salts derived from the corresponding carboxylic acids in the presence of halogens.

Although Borodine first reported this reaction in 1861 for the production of bromomethane from silver acetate and bromine, it was extensively investigated and put into practice by Hunsdiecker. Hence, the decomposition of carboxylic acid salts of Ag(I) in combination with a halogen source (such as bromine) into organic halides with one less carbon atom than the original acids is commonly referred to as the Hunsdiecker reaction.

It is worth noting that the Simonini reaction is a misnomer for this process.

Hunsdiecker Reaction - Borodine reaction
Hunsdiecker reaction
Hunsdiecker reaction - Borodine reaction - Hunsdiecker-Borodine reaction
Hunsdiecker reaction

The Hunsdiecker reaction finds widespread application in the synthesis of aliphatic halides.