What is Knoevenagel condensation?
The Knoevenagel condensation is a chemical process that involves the reaction of aldehydes or ketones with active methylene compounds in the presence of ammonia or amines. If the reaction involves malonic acid and pyridine, it is referred to as the Doebner modification.
References
- Knoevenagel, E. (1898), Condensation von Malonsäure mit aromatischen Aldehyden durch Ammoniak und Amine. [Condensation of malonic acid with aromatic aldehydes by ammonia and amines.] Ber. Dtsch. Chem. Ges., 31: 2596-2619. https://doi.org/10.1002/cber.18980310308
- Doebner, O. (1900), Synthese der Sorbinsäure. [Synthesis of sorbic acid.] Ber. Dtsch. Chem. Ges., 33: 2140-2142. https://doi.org/10.1002/cber.190003302121
