Kumada cross-coupling

What is Kumada cross coupling?

Kumada cross-coupling is a chemical reaction used in organic synthesis to synthesize new organic compounds. It involves the coupling of two organic molecules using a transition metal catalyst, typically nickel, palladium, or cobalt. The reaction was first reported in 1964 by Masatoshi Kumada, hence the name..

In the Kumada cross-coupling reaction, the starting materials are typically a halogenated organic compound and an organometallic compound, such as an organoboron or organozinc compound. The reaction occurs through a process called “transmetalation,” where the organometallic compound transfers its ligand (such as a boron or zinc atom) to the halogenated organic compound, forming a new bond between the two molecules. The transition metal catalyst facilitates the reaction by facilitating the transfer of the ligand from one molecule to the other..

One of the key advantages of Kumada cross-coupling is its high selectivity and efficiency. The reaction is highly selective for the desired product, meaning that it produces very little in the way of byproducts. This makes it a useful tool for synthesizing complex organic molecules with high purity..

Kumada cross-coupling has found a wide range of applications in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has also been used in the synthesis of polymers and materials for electronic applications..

Summary

Kumada cross-coupling is a valuable reaction for the synthesis of a wide range of organic compounds, due to its high selectivity and efficiency. It has had a significant impact on the field of organic synthesis and continues to be an important tool for the synthesis of complex organic molecules..

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