Ladenburg rearrangement

What is Ladenburg rearrangement?

The Ladenburg rearrangement is a chemical reaction that occurs through thermal rearrangement of an alkyl- or benzylpyridinium halide, leading to the formation of an alkyl- or benzylpyridine.

Ladenburg rearrangement
Ladenburg rearrangement

When N-alkyl or benzylpyridinium halides are heated, a rearrangement occurs to form a mixture of ortho– and para-alkylpyridinium halides, which eventually yields the corresponding o– and p-alkylpyridines.

References

Shares