Overman rearrangement

What is Overman rearrangement?

The Overman rearrangement is a formal [3,3]-sigmatropic rearrangement of the trichloroacetimidate of allylic alcohols to allylic trichloroacetamides. Thus, transposing the hydroxyl and amino functions with chirality transfer.

Overman rearrangement - general reaction scheme
Overman rearrangement

References

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