What is Perkin rearrangement?
The Perkin rearrangement is a chemical reaction that involves the contraction of the coumarin benzofuran ring. This reaction can be exemplified by the formation of both benzofuran-2-carboxylic acids and benzofurans, which occurs through the heating of 3-halocoumarins with an alkali.
References
W.H. Perkin, “XXIX.—On some new bromine derivatives of coumarin” J. Chem. Soc. 23, 368 (1870)
Full Professor of Organic Chemistry at the University of Granada, with a long-standing research career in Computational Chemistry and molecular modeling and design.