What is Brook rearrangement?
The Brook rearrangement is a chemical reaction that involves the base-catalyzed migration of silicon from carbon to oxygen in α-, β-, and γ-silyl alcohols. As a result of this reaction, silyl ethers are formed.
References
- Isomerism of Some α-Hydroxysilanes to Silyl Ethers
A. G. Brook
Journal of the American Chemical Society 1958 80 (8), 1886-1889
DOI: 10.1021/ja01541a026 - Isomerization of Some α-Hydroxysilanes to Silyl Ethers. II1
A. G. Brook, C. M. Warner, and Mary E. McGriskin
Journal of the American Chemical Society 1959 81 (4), 981-983
DOI: 10.1021/ja01513a056
Full Professor of Organic Chemistry at the University of Granada, with a long-standing research career in Computational Chemistry and molecular modeling and design.