Welcome to the Named Reactions category, where we explore the significant transformations in organic chemistry that bear the names of renowned chemists. Dive into the rich history and fundamental mechanisms behind reactions such as the Grignard reaction, Diels-Alder reaction, and Heck reaction, among others. Uncover the applications, limitations, and synthetic utility of these named reactions in organic synthesis. Discover how these reactions have shaped the field of organic chemistry and continue to inspire innovation. Embark on a journey through the world of named reactions and unlock the secrets of their chemical transformations.
What is Suárez reaction? The Suárez reaction, also known as Suárez fragmentation or Suárez cleavage, involves the photoinduced conversion of hydroxyl-containing substrates with hypervalent iodine I(III) I2, resulting in the formation of the corresponding oxygen-centered radical (see list of acronyms). References J.I. Concepción; C.G. Francisco; R. Hernández; J.A. Salazar; E. Suárez, “Intramolecular hydrogen abstraction. Iodosobenzene … Read more
What is Houben-Hoesch reaction? This reaction was first reported by Hoesch in 1915 and was extended subsequently by Houben in 1926. The Houben-Hoesch reaction is also referred to as the Hoesch synthesis, Houben-Hoesch condensation, Houben-Hoesch acylation, Houben-Hoesch synthesis, or Hoesch reaction. Moreover, the intramolecular version of such reaction is also known as the Houben-Hoesch cyclization. This Houben-Hoesch reaction involves … Read more
What is Haworth phenanthrene synthesis? The Haworth phenanthrene synthesis is a multi-step process used to prepare phenanthrenes from naphthalenes. The process involves several key steps, including Friedel-Crafts acylation, as well as two Clemmensen reductions or Wolff-Kishner reductions. These reactions work together to transform naphthalene into phenanthrene, which can then be utilized in a variety of industrial … Read more
What is Blanc rule? The Blanc rule was originally investigated by Lapworth in 1899 and later by Perkin in 1904 before being generalized by Blanc in 1907. Blanc reported that upon treatment with acetic anhydride, glutaric acid forms an intramolecular anhydride. Similarly, adipic and pimelic acids produce cyclopentanone and cyclohexanone respectively upon undergoing the same … Read more
What is Kucherov reaction? The Kucherov reaction, also referred to as the Kucherov coupling or Kucherov condensation, involves the hydration of acetylenic hydrocarbons in the presence of a catalyst, such as mercuric sulfate HgSO4 or boron trifluoride BF3, and dilute sulfuric acid H2SO4, yielding ketones. The Kucherov reaction is not commonly referred to by its … Read more
What are Norrish type I and type II reactions? Norrish type I and type II reactions are organic chemical reactions in which an alkene is converted into a carbonyl compound through the action of an ultraviolet light source. The reactions were discovered by the British chemist George Norrish in the 1950s and are named after … Read more
What is Steglich esterification? The Steglich catalyst, also known as 4-(N,N-dimethylamino)pyridine (DMAP), was first reported by Litvinenko and Kirichenko in 1967, and subsequently by Steglich in 1969. R, R1, R2 = alkyl, aryl R3 = H, alkyl, aryl (see list of acronyms) DMAP has been widely used as a super acylation catalyst for the preparation … Read more
What is Wagner-Meerwein rearrangement? The Wagner-Meerwein rearrangement, also known as the Wagner-Meerwein migration or Wagner-Meerwein shift. This reaction is a class of 1,2-rearrangement of carbocation intermediates, from which the migratory group (vinyl, phenyl, alkyl, H, …) (see list of acronyms) rearranges from an adjacent carbon atom to the carbocation center to form a more stable carbocation … Read more
