What is Doebner quinoline synthesis?
The Doebner quinoline synthesis, also referred to as the Doebner reaction or Döbner reaction, involves the synthesis of substituted cinchoninic acids (quinolines with a carboxylic acid group -COOH) from aromatic amines through a reaction with aldehydes and pyruvic acid upon heating.
References
- Döbner, O. (1887), 1) Ueber α-Alkylcinchoninsäuren und α-Alkylchinoline. [1) On α-alkylcinchoninic acids and α-alkylquinolines.] Justus Liebigs Ann. Chem., 242: 265-289. https://doi.org/10.1002/jlac.18872420302
- Doebner, O. (1887), Ueber α-Alkylcinchoninsäuren. [On α-alkylcinechoninic acids.] Ber. Dtsch. Chem. Ges., 20: 277-281. https://doi.org/10.1002/cber.18870200171
- Doebner, O. (1894), Die Synthese der α-Alkyl-β-naphtocinchoninsäuren, eine specifische Reaction auf Aldehyde, insbesondere zum Nachweis derselben in ätherischen Oelen. [The synthesis of α-alkyl-β-naphtocinchoninic acids, a specific reaction on aldehydes, especially for the detection of the same in essential oils.] Ber. Dtsch. Chem. Ges., 27: 352-354. https://doi.org/10.1002/cber.18940270172
- Doebner, O. (1894), Ueber die Synthese der α-Alkyl-β-naphtocinchoninsäuren, eine specifische Reaction auf Aldehyde. [On the synthesis of α-alkyl-β-naphtocinchoninic acids, a specific reaction on aldehydes.] Ber. Dtsch. Chem. Ges., 27: 2020-2030. https://doi.org/10.1002/cber.189402702169
