Prins reaction

What is Prins reaction?

The Prins reaction is  the acid-catalyzed addition of olefins to formaldehyde to give 1,3-diols, allylic alcohols or meta-dioxanes. The reaction was named after the Dutch chemist Hendrik Johannes Prins (1889-1958), who studied the reaction in greater detail in the 1919.

Prins reaction
Prins reaction


  • H.J. Prins, “Condensation of formaldehyde with some unsaturated compounds” Chem. Weekblad, 16, 64-74 (1919)
  • H.J. Prins, Chem. Weekblad, 16, 1072-1073 (1919)
  • H.J. Prins, Chem. Weekblad, 16, 1510-1526 (1919)