Quelet reaction

What is Quelet reaction?

The Quelet reaction involves passing dry hydrochloric acid through a solution of a phenolic ether and an aliphatic aldehyde in ligroin, with or without a dehydration catalyst. This results in the formation of α-chloroalkyl derivatives through substitution in the para position to the ether group or in the ortho position of para-substituted phenolic ethers. The reaction was first reported in literature in 1932, and is an important method for synthesizing α-chloroalkyl derivatives.

Quelet reaction
Quelet reaction

References

R. Quelet, Compt. Rend. 195, 155 (1932)

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