Wessely-Moser rearrangement

What is Wessely-Moser rearrangement?

The Wessely-Moser rearrangement is a chemical reaction that is specifically performed on flavones and flavanones containing a 5-hydroxyl group.

Wessely-Moser rearrangement - general reaction scheme
Wessely-Moser rearrangement

During the Wessely-Moser rearrangement, the heterocyclic ring undergoes fission and the resulting intermediate diaroylmethanes subsequently reclose in the opposite direction.


Wessely, F., Moser, G.H. Synthese und Konstitution des Skutellareins. [Synthesis and constitution of the scutellar stone.Monatshefte für Chemie 56, 97–105 (1930)
DOI: 10.1007/BF02716040