Wolff rearrangement

What is Wolff rearrangement?

The Wolff rearrangement is a chemical reaction that involves the conversion of diazoketones into ketenes. This reaction can be carried out using thermal, photochemical, or catalytic methods. The Wolff rearrangement is a crucial step in the Arndt-Eistert synthesis, a widely used organic chemical reaction that is used to elongate the carbon chain of carboxylic acids.

Wolff rearrangement
Wolff rearrangement

References

Wolff, L. and Krüche, R. (1912), Über Diazoanhydride (1,2,3-Oxydiazole oder Diazoxyde) und Diazoketone. [On diazoanhydrides (1,2,3-oxydiazoles or diazoxides) and diazoketones] Justus Liebigs Ann. Chem., 394: 23-59. https://doi.org/10.1002/jlac.19123940104

Shares