Welcome to the Named Reactions category, where we explore the significant transformations in organic chemistry that bear the names of renowned chemists. Dive into the rich history and fundamental mechanisms behind reactions such as the Grignard reaction, Diels-Alder reaction, and Heck reaction, among others. Uncover the applications, limitations, and synthetic utility of these named reactions in organic synthesis. Discover how these reactions have shaped the field of organic chemistry and continue to inspire innovation. Embark on a journey through the world of named reactions and unlock the secrets of their chemical transformations.
What is Chan-Evans-Lam cross coupling? The Chan-Evans-Lam cross coupling, also kown as Chan-Lam coupling, enables the formation of aryl carbon-heteroatom bonds by using oxidative coupling of arylboronic acids, stannanes, or siloxanes with compounds that contain N-H or O-H in the presence of air. Y = NR’, O, S, NCOR’, NSO2R’ The substrates that can be … Read more
What is Chichibabin amination? The Chichibabin amination, also known as Chichibabin reaction, is a chemical process that involves the introduction of an amino group to pyridines and other heterocyclic nitrogen compounds using alkali-metal amides. The reaction produces a primary amine, which can be subjected to further chemical modifications to enhance its functionality. The origin of … Read more
What is Allan-Robinson reaction? The synthesis of flavones or isoflavones derivatives through the condensation between o-hydroxyaryl ketones and an anhydride of aromatic acid was first reported by Allan and Robinson (Nobel Prize in Chemistry 1947) in 1924. As a result, the Allan-Robinson reaction is commonly referred to as the Allan-Robinson condensation, Allan-Robinson’s flavone synthesis, or … Read more
What is alkyne zipper reaction? The alkyne zipper reaction, also known as the Brown alkyne zipper reaction or alkyne isomerization reaction or alkyne-allene rearrangement, is a chemical process that involves the isomerization of internal alkynes into terminal alkynes by treating them with potasium 3-aminopropylamide (KAPA) or lithium 3-aminopropylamide (LiAPA) (see list of acronyms). The alkyne zipper reaction … Read more
What is Barton decarboxylation? The Barton decarboxylation is a two-step process that involves the radical decarboxylation of organic acids to produce alkanes. In 1983, Barton first reported this reaction, which generates thiohydroxamic acid esters of the organic acid, followed by the addition of a radical initiator and reagents that provide a good H-atom donor, such … Read more
What is Beckmann rearrangement? The Beckmann rearrangement is a chemical reaction in which an oxime is converted into an amide through the use of an acid catalyst (acid-mediated isomerization). This reaction was first described by Ernst Otto Beckmann in 1886, and it has since become a widely used method for the synthesis of amides. This … Read more
In this section, the most significant named organic reactions are listed, classified according to the type of chemical reaction. These reactions are carried out with multiple mechanisms involved and some of them with multistep synthesis Among the organic reactions with a name of the multiple mechanisms we can highlight the following: Back to the Named Organic … Read more
What are addition reactions to multiple C-C bonds? Addition reactions to multiple C-C bonds take place when a functional group is added to a carbon-carbon double (C=C) or triple (C≡C) bond, reducing their bond order. This section lists the most significant named organic reactions classified according to the type of chemical reaction. Among the named … Read more
What is Zerewitinoff determination? The Zerewitinoff determination is a method to quantitatively determine the active hydrogens in a chemical substance by adding methylmagnesium iodide in pentyl ether to the solution of substrate and measuring the volume of gaseous methane evolved. The reaction was first reported by Chugaev and subsequently extended by Zerewitinoff. The method is … Read more
What is Zemplén deacetylation? The Zemplén deacetylation is a reaction that was first reported by Zemplén and Kuntz in 1924. It is a useful method for the removal of O-acetyl protecting groups of carbohydrates, and it is performed by treating the O-acetylated substrates with a catalytic amount of sodium methoxide in methanol at room temperature. … Read more
